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The higher the number, the greater tread life you should expect. A tire with a grade of 200 should give you twice as much mileage as one rated at 100, provided that you keep the tires inflated properly, the wheels aligned and tires balanced and drive then under normal conditions.
Failure to care for your tires will greatly reduce the tread life and can also create a safety hazard. How you drive, and under what road conditions, also affect treadwear.